American Journal of Medical and Pharmacy Research (AJMPR)
Lycopene Action On Cyclooxygenase and Lipid Peroxidation in Dexamethasone-Actuated Oxidative Worry in Wistar Rodents
(This article belongs to Vol - 01, Issue - 01)
This examination was gone for exploring lycopene action on cyclooxygenase and lipid peroxidation in dexamethasone-treated Wistar rodents. Twenty (20) male Wistar rodents weighing between 150g-250g were haphazardly chosen into four gatherings containing five rodents each. Control rodents got standard feed and water. Gathering two got 3mg/kg body weight of dexamethasone intraperitoneally every two days for 9 days. Gathering 3 got 3mg/kg body weight of dexamethasone intraperitoneally every two days for 9 days in addition to day by day oral organization of 1mg/kg of lycopene for 28 days. Results demonstrated that there was no critical distinction in the action of dexamethasone and lycopene on COX and THX-A 2 in every one of the gatherings. Dexamethasone expanded AST ALT and ALT level. Treatment with Lycopene fundamentally (p<0.01) diminished AST, ALT, and ALP in every one of the gatherings. Lactate dehydrogenase movement was fundamentally (p<0.01) diminished in the dexamethasone and further brought down upon treatment with lycopene when contrasted with the DEX gathering. Malondialdehyde (MDA) fixation in Dex was expanded (p<0.01), Catalase action was diminished while SOD focus was not modified. Treatment with lycopene Significantly (p<0.01) diminished serum MDA and expanded catalase fixation. Triglyceride and LDL segments of the lipid were raised in Dex with a diminished HDL however without modification in complete cholesterol level. Lycopene diminished the TC, LDL, and TG and fundamentally (p<0.01) expanded HDL. It is presumed that dexamethasone stifles cyclooxygenase articulation however potentiates lipid peroxidation and builds liver compounds. Lycopene hinders Cox movement, secure against lipid peroxidation and is hypolipidemic and hepatoprotective.