Abstract

To study the correlation between the expression of tumor microenvironment receptors and molecular biological subtypes of breast cancer, as well as their effect on prognosis. To improve the diagnosis and treatment of breast cancer by studying the tumor microenvironment, its impact on the course and prognosis, we analyzed a group of 457 breast cancer patients. PD-1, PD-L1, EGFR and CK 5/6 in luminal tumors had lower values than in triple-negative forms of breast cancer. In luminal type A - PD-1=30%, PD-L 1 - 17.7%, EGFR - 5.9%, and CK 5/6-3.3%, whereas in triple-negative cancers, these indicators were 61.7%, 39.8%, and 53.4%, respectively. Data analysis showed that there is a strong correlation between the expression of the above markers and molecular biological subtypes of breast cancer.