Journal of Chemical Engineering and Applied Chemistry (JCEAC)
Union and Characterization of Molecularly Imprinted Polymer for Prasugrel Drug Base on 2-Hydroxyethyl Methacrylate Monomer in Biological and Pharmaceutical Samples
(This article belongs to Vol - 01, Issue - 01)
In this examination work, a molecularly engraved polymer (MIP) was integrated for Prasugrel. In this technique, a polymer was first orchestrated utilizing 2-hydroxyethyl methacrylate (HEMA) as a monomer, N, N'- methylenebisacrylamide as a crosslinker, and azobisisobutyronitrile (AIBN) as an initiator. The fruitful blend of the MIP was affirmed by essential investigation (CHN), Fourier-change infrared (FT-IR) spectroscopy and checking electron microscopy (SEM). At that point, the impacts of different parameters, for example, pH, temperature, MIP limit, selectivity, adsorption energy and adsorption isotherms were examined by UV-Vis spectroscopy. The adjustment bend was plotted for Prasugrel in these conditions and direct range, point of confinement of recognition (LOD) and cutoff of measurement (LOQ) were accounted for. At long last, the presentation of the combined MIP as an adsorbent was considered under upgraded conditions for the extraction and assurance of Prasugrel in tablet framework and natural liquids, for example, pee and plasma by superior fluid chromatography (HPLC).